Nicotine itself isn't addictive, but it is in charge of releasing dopamine, a neurotransmitter associated with pleasure and reinforcements from the mind, thus inducing addictive tendencies in humans. Nicotine is a chemical found in tobacco leaf, E-Zigarette the principal ingredient in cigarettes and is supposed to cause addiction and disease in cigarette smokers, (World Health Organization (WHO)).

Nicotine mimics the activities of acetylcholine, a naturally occurring neurotransmitter in the central nervous system along with the nerve-muscle junction of skeletal muscles. Acetylcholine is responsible for excitability, which causes increase heart rate, alertness, and response times, (Psychopharmacology (Berl). .

Since acetylcholine and nicotine are similar, they activate the identical cholinergic receptors within the brain. The nicotine-acetylcholine receptors consist of nerve endings which release dopamine when combined or bind with nicotine or acetylcholine. Receptors are like cups having the specific measurements which will fit a neurotransmitter molecule, like acetylcholine.

The cup itself is lined with nerve endings (hints of neurons). It is these nerve endings that release dopamine when the neurotransmitter acetylcholine binds using the cup-like acetylcholine receptors (cholinergic receptors).

A reinforcing and reward phenomenon of dopamine develops because the dopamine that's released from the nerve endings initiates a sense of pleasure in somebody's brain. The reinforcement mechanism is initiated when the brain becomes addicted to the pleasure brought on by the dopamine that's released from the cholinergic receptors. This usually means that the brain is constantly seeking to be pleasured. Thus, E Zigarette what's going to occur in the case of cigarette smokers is that they will continue to smoke cigarettes so that the nicotine in the cigarette can induce the release of dopamine within the brain, making them feel happy each time they smoke a cigarette, (Nature Reviews Neuroscience 7, 967-975 (December 2006)).